Inhibition of focal adhesion kinase (FAK) rescued SERT function in synapses of KI mice, demonstrating that constitutive Lively FAK signaling downstream with the Pro32Pro33 integrin αvβ3 suppresses SERT activity. Our research discover a fancy regulation of 5-HT homeostasis and behaviors by integrin αvβthree, revealing an important role for integrins in modulating threat for neuropsychiatric Conditions.
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With each other, these information suggest that integrin αvβthree receptors dynamically control SERT uptake action and level to novel pathways which might be qualified pharmacologically for that amelioration of 5-HT-dependent deficits in adult animals.
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